INDICATIONS
IN vitro hemoDynamIc charaCterizATIon Of a traNscatheter mitral valve prOsthesiS
Scheda del progetto
The INDICATIONS project is a consulting service provided by PAsTISs to the company Epygon Italie S.r.l. for the in vitro characterization of fluid dynamics in the left ventricle after implantation of a minimally invasive mitral valve prosteshis, aimed at restoring natural blood flow.
Using Particle Imaging Velocimetry (PIV) on a hydraulic circuit that simulates systemic circulation, the effect of the prosthesis on blood flow velocities and flow characteristics in the ventricle will be assessed.
These experimental tests are crucial for evaluating the effectiveness of the prosthesis in improving ventricular energy and reducing the risks of post-implantation thrombosis.
Contact:
Mauro Ferraro
The service request aims to develop a testing platform capable of replicating natural hemodynamic conditions and providing measurable validation of the expected behavior of the bioprosthesis. This will allow to optimize the process and design, as well as the generation of relevant data for the study of the clinical impact of ventricular hemodynamics following bioproshesis implantation.
The service requested by the company has a considerable innovative value with the development of a dedicated setup to replicate the hemodynamic conditions of the left ventricle. The technical challenges include the redesign of the optical access camera and the development of a dedicated setup to replicate the hemodynamic conditions of the left ventricle. The technical challenges include redesign of the optical access camera and the development of the image capture and processing system, making the offer technologically competitive compared to other European laboratories.
The creation of a digital archive of evidence and results will facilitate the engineering evaluation of the expected benefits of the valve and support the study of new generations of valves. The results will provide R&D department with new expertise in the hemodynamic analysis of valves and enable statistical comparisons between different design solutions.
The results of the service will have significant impacts on various stakeholders: the R&D Department at Epygon Italia will benefit from the generation of know-how and increased prodution efficiency, reducing costs in the development of new products: Epygon Italy's management could leverage the results for marketing purposes if superiority over competitors is demonstrated; end users, including cardiac surgeons, will gain a better understanding of the benefits of the developed valve; finally, regulatory authorities will obtain clear and quantifiable evidence of the valve's efficacy, simplifying approval and evaluation of its benefits.